Xenotransplantation and AIDS: Retroviral prevalence in the non-human primate donor

Academic Article

Abstract

  • Modern immunosuppressive techniques and drug regimes hold much promise in terms of the viability of utilizing non-human primates as organ donors failing cadaveric donor organ procurement. Consideration must, however, be given to the substantial viral prevalence associated with these animals, in particular, to those retroviral strains implicated through their serological cross-reactivity within HIV-I to AIDS. Colony bred animals were seen to exhibit a reduced retroviral prevalence when compared to animals captured in the wild. This finding, together with the reduced virological status in primates preselected against retroviral seropositivity, has clinical significance. (AIFO 4,188-190,1989)
  • Authors

    Author List

  • Human P; Van der Riet F; Cooper D; Fincham J; Kalter S; Reichart B
  • Start Page

  • 188
  • End Page

  • 190
  • Volume

  • 4
  • Issue

  • 4