Laminar air flow isolation and decontamination: A prospective randomized study of the effects of prophylactic systemic antibiotics in bone marrow transplant patients

Academic Article


  • 122 patients with hematologic malignancies underwent allogeneic marrow transplantation from HLA-matched sibling donors and received one of two forms of infection prophylaxis while granulocytopenic: 1) decontamination and laminar air flow isolation (LAF, 68 patients), and 2) LAF plus prophylactic systemic antibiotics (LAF+PSA, 54 patients). Patients were evaluated for infection acquisition while in isolation. Septicemia occurred in 11 (16%) of the patients in the LAF group and in three (6%) patients in the LAF+PSA group. Fourteen (21%) of the patients in the LAF group and four (7%) patients in the LAF+PSA group had a major local infection. There was no difference in the incidence and severity of graft-versus-host disease or incidence and duration of fever. The addition of prophylactic intravenous broad-spectrum antibiotics for patients isolated in LAF rooms significantly decreased infection acquisition. © 1986 MMV Medizin Verlag GmbH München.
  • Published In

  • Infection  Journal
  • Digital Object Identifier (doi)

    Author List

  • Petersen FB; Buckner CD; Clift RA; Lee S; Nelson N; Counts GW; Meyers JD; Sanders JE; Stewart PS; Bensinger WI
  • Start Page

  • 115
  • End Page

  • 121
  • Volume

  • 14
  • Issue

  • 3