A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships

Academic Article


  • Non-steroidal anti-inflammatory drugs (NSAIDs) have a variety of potential indications that include management of pain and inflammation as well as chemoprevention and/or treatment of cancer. Furthermore, a specific form of ibuprofen, dexibuprofen or the S-(+) form, shows interesting neurological activities and has been proposed for the treatment of Alzheimer's disease. In a continuation of our work probing the anticancer activity of small sulindac libraries, we have prepared and screened a small diversity library of α-methyl substituted sulindac amides in the profen class. Several compounds of this series displayed promising activity compared with a lead sulindac analog.
  • Digital Object Identifier (doi)

    Author List

  • Mathew B; Snowden TS; Connelly MC; Guy RK; Reynolds RC
  • Start Page

  • 2136
  • End Page

  • 2142
  • Volume

  • 28
  • Issue

  • 12