Presentation of antigen by B cell subsets. III. Effects of interleukins on antigen presenting function and phenotype of immature B cells.

Academic Article

Abstract

  • In this report we demonstrate that B cells from CBA/N or (CBA/N x BALB/c)F1 male mice with x-linked immunodeficiency, that have very limited ability to present antigen to antigen-specific T cells, acquire this function following preincubation with IL-1, IL-4 and to a lesser degree with IL-6 and IL-5. Preincubation of normal B cells with these B-tropic interleukins does not lead to enhancement of their APC function. Incubation of B cells from the peritoneal cavity and spleen of xid mice with B cell tropic interleukins (IL-1, 4, 5 and 6), but not with IL-2 or IL-3, induces appearance of Lyb-5 antigen on these cells. The study demonstrates that the property of inducing APC activity in immature B cells is correlated with the acquirement of Lyb-5 antigen.
  • Authors

    Author List

  • Zimecki M; Kapp JA
  • Start Page

  • 355
  • End Page

  • 359
  • Volume

  • 42
  • Issue

  • 5-6