Genetic tagging shows increased frequency and longevity of antigen-presenting, skin-derived dendritic cells in vivo

Academic Article

Abstract

  • Dendritic cells (DCs) are key regulators of immune responses that activate naive antigen-specific T lymphocytes. In draining lymh nodes, antigen-bearing DCs are reported to be rare and short-lived. How such small numbers of short-lived DCs can activate rare antigen-specific T cells is unclear. Here we show that after immunization of mouse skins by gene gun, the number of antigen-bearing DCs that migrate to draining lymph node is 100-fold higher than previously estimated and that they persist for approximately 2 weeks. The substantial frequency and longevity of DCs in situ ensures ample antigen presentation and stimulation for the rare antigen-specific T cells in draining lymph nodes.
  • Authors

    Published In

  • Nature Immunology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Garg S; Oran A; Wajchman J; Sasaki S; Maris CH; Kapp JA; Jacob J
  • Start Page

  • 907
  • End Page

  • 912
  • Volume

  • 4
  • Issue

  • 9