Suppression of antibody and T cell proliferative responses to L-glutamic acid60-L-alanine30-L-tyrosine10 by a specific monoclonal T cell factor

Academic Article

Abstract

  • The synthetic terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) stimulates GAT specific suppressor T cells in nonresponder mice. Extracts from these T cells contain a GAT-specific soluble T cell suppressor factor (GAT-TsF) that inhibits development of GAT-specific plaque-forming cell (PFC) responses by spleen cells from nonresponder mice stimulated with GAT complexed to methylated bovine serum albumin (GAT-MBSA). These extracts also contain a factor that inhibits development of GAT-specific proliferative responses by GAT-MBSA-primed, nonresponder lymph node T cells. Experiments reported in this manuscript show that a hybrid T cell line, produced by fusion of the AKR thymoma, BW5147, with spleen cells that contain GAT-specific suppressor T cells, produces a constitutive GAT-specific suppressor factor that functionally and serologically resembles GAT-TsF extracted from T cells. More importantly, both GAT-specific and PFC and T cell proliferative responses are inhibited by this factor.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Kapp JA; Araneo BA; Clevinger BL
  • Start Page

  • 235
  • End Page

  • 240
  • Volume

  • 152
  • Issue

  • 1