Growth in North American white children with neurofibromatosis 1 (NF1)

Academic Article


  • Objective - To analyse the distributions of and generate growth charts for stature and occipitofrontal circumference (OFC) in neurofibromatosis 1 (NF1) patients. Design - Cross sectional database survey. Setting - The National Neurofibromatosis Foundation International Database (NFDB) includes clinical information on NF1 patients from 14 participating centres in North America. Subjects - A total of 569 white, North American, NF1 patients, 55% female and 45% male. Main outcome measures - Stature and OFC measurements of NF1 patients were compared to age and sex matched population norms using z score standardisation and centile curves. Results - The distributions of stature and OFC are shifted and unimodal among NF1 patients; 13% of patients have short stature (≥2 standard deviations below the population mean) and 24% have macrocephaly (OFC ≥2 standard deviations above the population mean). Conclusions - Alterations of stature and OFC are not limited to NF1 patients with frank short stature or macrocephaly.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Szudek J; Birch P; Friedman JM; Burke W; Bennett R; de Campos JM; Korf B; Krause W; Uhas K; Niimura M
  • Start Page

  • 933
  • End Page

  • 938
  • Volume

  • 37
  • Issue

  • 12