CNS inflammation and bone marrow neuropathy in type 1 diabetes

Academic Article


  • By using pseudorabies virus expressing green fluorescence protein, we found that efferent bone marrow-neural connections trace to sympathetic centers of the central nervous system in normal mice. However, this was markedly reduced in type 1 diabetes, suggesting a significant loss of bone marrow innervation. This loss of innervation was associated with a change in hematopoiesis toward generation of more monocytes and an altered diurnal release of monocytes in rodents and patients with type 1 diabetes. In the hypothalamus and granular insular cortex of mice with type 1 diabetes, bone marrow-derived microglia/macrophages were activated and found at a greater density than in controls. Infiltration of CD45 /CCR2 /GR-1 /Iba-1 bone marrow-derived monocytes into the hypothalamus could be mitigated by treatment with minocycline, an anti-inflammatory agent capable of crossing the blood-brain barrier. Our studies suggest that targeting central inflammation may facilitate management of microvascular complications. Copyright © 2013 American Society for Investigative Pathology. + + + +
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Hu P; Thinschmidt JS; Yan Y; Hazra S; Bhatwadekar A; Caballero S; Salazar T; Miyan JA; Li W; Derbenev A
  • Start Page

  • 1608
  • End Page

  • 1620
  • Volume

  • 183
  • Issue

  • 5