Immunological self, nonself discrimination

Academic Article

Abstract

  • The ability of immunodominant peptides derived from several antigen systems to compete with each other for T cell activation was studied. Only peptides restricted by a given transplantation antigen are mutually competitive. There is a correlation between haplotype restriction, ability to bind to the appropriate transplantation antigen, and ability to inhibit activation of other T cells restricted by the same transplantation antigen. An exception was noted in that a peptide derived from an antigen, bacteriophage lambda cI repressor, binds to the I-E molecule in a specific way, yet is not I-E -restricted. Comparison of the sequence of the repressor peptide with that of other peptides able to bind to (and be restricted by) I-E and a polymorphic region of the I-E molecule itself revealed a significant degree of homology. Thus, peptides restricted by a given class II molecule appear to be homologous to a portion of the class II molecule itself. The repressor-derived peptide is identical at several polymorphic residues at this site, and this may account for the failure of I-E to act as a restriction element. Comparison of antigenic peptide sequences with transplantation antigen sequences suggests a model that provides a basis for explaining self, nonself discrimination as well as alloreactivity. d d d d d
  • Authors

    Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 17596253
  • Author List

  • Guillet JG; Lai MZ; Briner TJ; Buus S; Sette A; Grey HM; Smith JA; Gefter ML
  • Start Page

  • 865
  • End Page

  • 870
  • Volume

  • 235
  • Issue

  • 4791