Nucleotide sequences of the human and mouse atrial natriuretic factor genes

Academic Article


  • Mouse and human atrial natriuretic factor (ANF) genes have been cloned and their nucleotide sequences determined. Each ANF gene consists of three coding blocks separated by two intervening sequences. The 5́ flanking sequences and those encoding proANF are highly conserved between the two species, while the intervening sequences and 3́ untranslated regions are not. The conserved sequences 5́ of the gene may play an important role in the regulation of ANF gene expression.
  • Authors

    Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 6753738
  • Author List

  • Seidman CE; Bloch KD; Klein KA; Smith JA; Seidman JG
  • Start Page

  • 1206
  • End Page

  • 1209
  • Volume

  • 226
  • Issue

  • 4679