Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

Academic Article


  • A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor. © 1987 Nature Publishing Group.
  • Authors

    Published In

  • Nature  Journal
  • Pubmed Id

  • 20429491
  • Author List

  • Sette A; Buus S; Colon S; Smith JA; Miles C; Grey HM
  • Start Page

  • 395
  • End Page

  • 399
  • Volume

  • 328
  • Issue

  • 6129