A novel recombinant immunotoxin-based therapy targeting wild-type and mutant EGFR improves survival in murine models of glioblastoma

Academic Article


  • Both the amplification of the gene coding for wild-type (wt) epidermal growth factor receptor (EGFR) and the overexpression of the EGFR deletion mutant, commonly known as EGFRvIII, are hallmarks of glioblastoma. We have recently reported a novel, recombinant immunotoxin, D2C7-(scdsFv)-PE38KDEL, that targets both wt EGFR and EGFRvIII, exhibiting potent antineoplastic effects against established murine gliomas. © 2013 Landes Bioscience.
  • Authors

    Published In

  • OncoImmunology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Chandramohan V; Bigner DD
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  • 1
  • End Page

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  • Volume

  • 2
  • Issue

  • 12