Immunogenetic Analysis of H‐2 Mutations: IV. Mapping of and Immune Reactions to the H‐2fa Mutation

Academic Article

Abstract

  • H‐2fa is a spontaneous mutation that occurred in an (A.CA × A)F1 female mouse and was later transferred on an A‐strain background [congenic line A.CA(M506) or M506]. Skin grafts exchanged between M506 and A.CA strains are rejected within 4 weeks after grafting. Significant reaction is observed when these two strains are used as responders and stimulators in mixed lymphocyte culture or in a splenomegaly graft‐versus‐host assay. The mutant antigen induces strong cell‐mediated lymphocytotoxicity. The mutation maps in the K end of the H‐2 complex. The capacity of mutant antigens to induce relatively strong lymphocyte proliferation is explained by hypothesizing that the T‐cell receptors reacting with K‐ or D‐region products can more easily recognize subtle than drastic alloantigenic differences. Copyright © 1976, Wiley Blackwell. All rights reserved
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 7565835
  • Author List

  • KLEIN J; EGOROV IK; MNATSAKANYAN YA; HAUPTFELD V
  • Start Page

  • 521
  • End Page

  • 528
  • Volume

  • 5
  • Issue

  • 5