Enhancement in 'apparent' membrane microviscosity during differentiation of embryonal carcinoma cells induced by retinoids

Academic Article

Abstract

  • Upon differentiation of embryonal carcinoma cells induced by retinoids (10-7 M) the 'apparent' membrane microviscosity increases dramatically. Only biologically active retinoids induce differentiation and cause an enhancement in microviscosity. Several embryonal carcinoma cell lines have a relatively lower 'apparent' microviscosity than their differentiated derivatives, suggesting that this may be a general property of these cells. At higher concentrations retinoids cause a reduction in 'apparent' membrane microviscosity of various cells. This change occurs whether the analogue is biologically active or not, indicating the non-specific nature of this action. © 1982.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 8903259
  • Author List

  • Jetten AM; De Luca LM; Meeks RG
  • Start Page

  • 494
  • End Page

  • 498
  • Volume

  • 138
  • Issue

  • 2