Developmentally controlled expression of immunoglobulin VH genes

Academic Article

Abstract

  • Although antibody diversity arises mainly from apparently random combinatorial and somatic mutational mechanisms acting upon a limited number of germline antibody genes, the antibody repertoire develops in an ordered fashion during mammalian ontogeny. A series of early pre-B and B-lymphocyte cell lines were examined to determine whether an ordered rearrangement of gene families of the variable region of immunoglobulin heavy chains (V ) may be the basis for the programmed development of the antibody response. The results indicated that the V repertoire of fetal B-lineage cells is largely restricted to the V 7183 gene family and that subsequent recruitment of additional V gene families occurs during neonatal development. These results have important implications in understanding the ontogeny of immune function. H H H H
  • Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Perlmutter RM; Kearney JF; Chang SP; Hood LE
  • Start Page

  • 1597
  • End Page

  • 1601
  • Volume

  • 227
  • Issue

  • 4694