Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement

Academic Article


  • Switching of an Abelson virus-transformed mouse lymphoid cell line from immunoglobulin μ to γ2b heavy-chain synthesis in vitro is accompanied by loss of DNA sequences between the JH and Cγ2b gene segments, and thus cannot be explained by differential RNA processing. The light-chain loci of both μ- and γ2b-producing cell clones are in the embryonic configuration, which indicates that class switching can occur in pre-B cells. © 1983 Nature Publishing Group.
  • Authors

    Published In

  • Nature  Journal
  • Digital Object Identifier (doi)

    Author List

  • Burrows PD; Beck-Engeser GB; Wabl MR
  • Start Page

  • 243
  • End Page

  • 246
  • Volume

  • 306
  • Issue

  • 5940