Feasibility of primary clot extraction prior to percutaneous coronary intervention in acute myocardial infarction

Academic Article


  • Objectives: To test the feasibility, safety, and in-hospital outcomes of utilizing the Filter-Wire EZ to extract clot prior to percutaneous coronary intervention (PCI) in patients presenting with acute myocardial infarction (Ml). Background: PCI in patients with acute Ml is associated with a higher incidence of distal embolization, no-reflow, or slow flow partly due to the presence of clot burden. Methods: The authors describe the feasibility, safety, and outcomes of using a FilterWire EZ distal protection device as a clot extraction device in patients who presented with acute Ml and documented clot on coronary angiography. Results: Fifteen consecutive male patients with a mean age of 54 ± 8 years presented with acute Ml (60% ST elevation Ml). Ml involved left anterior descending artery (n = 4), circumflex artery (n = 3), and right coronary artery (n = 8). Clot extraction followed by PCI reduced the percent diameter stenosis from 94 ± 12 to 65 ± 11 (P < 0.001) and restored TIMI 3 flow in all patients without distal embolization. The angiographic, procedural, and clinical success rates were 100%. The mean left ventricular ejection fraction (LVEF) was 52 ± 8% (range 30-62%) with only three patients (15%) who had an LVEF <50% and five patients (33%) without apparent wall motion abnormalities on echocardiography. Conclusions: Clot extraction before PCI during acute Ml in native coronaries is feasible, safe, and effective in restoring TIMI 3 flow without distal embolization. Whether this approach results in better outcomes and improved LV function compared with standard therapy alone requires further investigation. © 2008 Wiley-Liss, Inc.
  • Digital Object Identifier (doi)

    Author List

  • Aqel R; Zoghbi G; Hage F; Philips G; Perry G; Iskandrian A; Dell'Italia L
  • Start Page

  • 870
  • End Page

  • 876
  • Volume

  • 71
  • Issue

  • 7