To the Editor: Despite the promising potential for oral levodopa in the treatment of heart failure noted by Rajfer et al. (May 24 issue),* we have recently encountered a case emphasizing the experimental nature of this medication. A patient was transferred to our hospital after continued progression of chronic heart failure despite medical management at a community hospital. The patient was a 74-year-old woman with idiopathic cardiomyopathy whose clinical status worsened considerably with a four-day titration of levodopa to a total dose of 1 g by mouth every six hours. Other medications at the time of transfer included digoxin (0.125. © 1984, Massachusetts Medical Society. All rights reserved.