Is early-pregnancy proteinuria associated with an increased rate of preeclampsia in women with pregestational diabetes mellitus?

Academic Article

Abstract

  • Objective: The purpose of this study was to determine whether the rate of preeclampsia in pregnant diabetic women is increased in those women with early-pregnancy proteinuria of 190 to 499 mg/24 hours compared with women with proteinuria of < 190 mg/24 hours. Study design: Secondary analysis was performed with relevant data from 194 pregnant women with type 1 and type 2 diabetes mellitus whose condition required insulin and who were enrolled previously in a multicenter trial of low-dose aspirin for the prevention of preeclampsia. The women were assigned to 1 of 3 groups, based on the level of proteinuria at enrollment (13-26 weeks of gestation). Group 1 comprised women with < 190 mg protein/24 hours (n = 94); group 2 comprised women with 190 to 499 mg protein/24 hours (n = 35); and group 3 comprised women with ≥ 500 mg protein/24 hours (n = 65). The rate of preeclampsia, according to strict predefined criteria, was then determined. Results: The rate of preeclampsia was not increased statistically significantly in patients with early-pregnancy proteinuria of 190 to 499 mg/24 hours (7/35 women; 20%) when compared with women with proteinuria of < 190 mg/24 hours (16/94 women; 17%). Conclusion: We did not find an increased rate of preeclampsia in women with pregestational diabetes mellitus with early-pregnancy proteinuria of 190 to 499 mg/24 hours when compared with women with pregestational diabetes mellitus with proteinuria of < 190 mg/24 hours. © 2004 Elsevier Inc. All rights reserved.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • How HY; Sibai B; Lindheimer M; Caritis S; Hauth J; Klebanoff M; MacPherson C; Van Dorsten P; Miodovnik M; Landon M
  • Start Page

  • 775
  • End Page

  • 778
  • Volume

  • 190
  • Issue

  • 3