Challenges and opportunities for pediatric severe TBI—review of the evidence and exploring a way forward

Academic Article


  • Traumatic brain injury (TBI) is a leading killer of children in the developed and developing world. Despite evidence-based guidelines and several recent clinical trials, the progress in developing best practices for children with severe TBI has been slow. This article describes (i) the burden of the disease, (ii) the inadequacies of the evidence-based guidelines, (iii) the failure of the largest clinical trials to prove their primary hypotheses, and (iv) possible advances from an observational cohort study called the Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial that has recently completed enrollment.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Bell MJ; Adelson PD; Wisniewski SR; Agrawal S; Mahoney S; Gupta D; Beca J; Loftis L; Morris K; Piper L
  • Start Page

  • 1663
  • End Page

  • 1667
  • Volume

  • 33
  • Issue

  • 10