Systematic review and case series of neuropsychological functioning after epilepsy surgery in children with dysembryoplastic neuroepithelial tumors (DNET)

Academic Article


  • Rationale: The purposes of this study were to 1) conduct a review of neuropsychological (NP) outcomes after epilepsy surgery for DNET and 2) present pre/post-surgical NP results from a series of children with DNET. Methods: First, a systematic literature review was conducted with specific inclusion criteria. Second, a review of DNET surgical patients seen at two tertiary-care hospitals using reliable change methods of NP functioning was conducted. Results: Of 300 citations retrieved, 7 studies met criteria. Studies reported low average to average pre-surgical IQ. Engel Class I outcome was approximately 85%. Case Series: Thirteen children completed pre/post-surgical NP assessments. Pre-surgically, children demonstrated low average to average functioning. Post-surgically, few patients showed reliable change. One-third of children demonstrated psychological improvement. Conclusions: NP outcome following DNET has not been well-described. Children with DNET demonstrate low average to average NP functioning pre-surgically, good seizure outcome, and stable NP functioning post-surgically. © 2011 Elsevier Inc.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Fay-McClymont TB; Hrabok M; Sherman EMS; Hader WJ; Connolly MB; Akdag S; Mohamed IS; Wiebe S
  • Start Page

  • 481
  • End Page

  • 486
  • Volume

  • 23
  • Issue

  • 4