Lambert-Eaton Myasthenic Syndrome

Academic Article


  • Lambert-Eaton myasthenic syndrome is a paraneoplastic or primary autoimmune neuromuscular junction disorder characterized by proximal weakness, autonomic dysfunction and ariflexia. The characteristic symptoms are thought to be caused by antibodies generated against the P/Q-type voltage-gated calcium channels present on presynaptic nerve terminals and by diminished release of acetylcholine. More than half of Lambert-Eaton myasthenic syndrome cases are associated with small cell lung carcinoma. Diagnosis is confirmed by serologic testing and electrophysiologic studies. 3,4-diaminopyridine is effective symptomatic treatment of LEMS.
  • Authors

    Published In

  • Neurologic Clinics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Kesner VG; Oh SJ; Dimachkie MM; Barohn RJ
  • Start Page

  • 379
  • End Page

  • 394
  • Volume

  • 36
  • Issue

  • 2