Exendin-4 decreases amphetamine-induced locomotor activity

Academic Article


  • Glucagon-like peptide-1 (GLP-1) is released in response to nutrient ingestion and is a regulator of energy metabolism and consummatory behaviors through both peripheral and central mechanisms. The GLP-1 receptor (GLP-1R) is widely distributed in the central nervous system, however little is known about how GLP-1Rs regulate ambulatory behavior. The abused psychostimulant amphetamine (AMPH) promotes behavioral locomotor activity primarily by inducing the release of the neurotransmitter dopamine. Here, we identify the GLP-1R agonist exendin-4 (Ex-4) as a modulator of behavioral activation by AMPH. We report that in rats a single acute administration of Ex-4 decreases both basal locomotor activity as well as AMPH-induced locomotor activity. Ex-4 did not induce behavioral responses reflecting anxiety or aversion. Our findings implicate GLP-1R signaling as a novel modulator of psychostimulant-induced behavior and therefore a potential therapeutic target for psychostimulant abuse. © 2012 Elsevier Inc.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Erreger K; Davis AR; Poe AM; Greig NH; Stanwood GD; Galli A
  • Start Page

  • 574
  • End Page

  • 578
  • Volume

  • 106
  • Issue

  • 4