INTRODUCTION: Reduction mammoplasty in patients with gigantomastia can prove a challenge for the plastic surgeon. Although several techniques have been described to reduce these very large breasts, they can often result in compromise of the nipple-areola complex (NAC), including necrosis, decreased sensation, and inability to breastfeed. The superomedial pedicle (SMP) reduction mammoplasty technique has been demonstrated as a safe and effective method of reduction in cases of mild to moderate hypertrophy. The aim of this study was to determine the risks of SMP in patients with gigantomastia (resection weight >1000 g/breast) at our institution. METHODS/TECHNIQUE: A retrospective study of all patients who underwent reduction mammoplasty with SMP technique by 8 surgeons at a single institution between 1999 and 2011 was performed. Patient demographics, preoperative breast measurements, and perioperative data were analyzed. Exclusion criteria were a reduction mammoplasty specimen weight of less than 1000 g. RESULTS/COMPLICATIONS: Our results show that 200 of 1750 patients who underwent SMP during the study period met the criteria. The average age at the time of the reduction was 39 years. The average body mass index was 36 kg/m. The average sternal notch to nipple distance was 35.5 cm for the right breast and 35.6 cm for the left breast. Average breast resection weight was 1277 g for the right and 1283 g for the left. Average NAC transposition was 11.25 cm for the right breast and 11.40 cm for the left breast. Twenty-one (10.5%) patients experienced partial necrosis of the NAC and 98% of the patients subjectively reported normal NAC sensation postoperatively. All patients exhibited good breast shape and projection postoperatively. CONCLUSIONS: Our study shows that SMP reduction mammoplasty in patients with gigantomastia is a safe and effective reduction mammoplasty technique and is associated with low risk for NAC necrosis with good breast shape. Copyright © 2013 by Lippincott Williams and Wilkins.