Maternal BMI, glucose tolerance, and adverse pregnancy outcomes

Academic Article

Abstract

  • OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values. © 2012 Mosby, Inc. All rights reserved.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Stuebe AM; Landon MB; Lai Y; Spong CY; Carpenter MW; Ramin SM; Casey B; Wapner RJ; Varner MW; Rouse DJ
  • Start Page

  • 62.e1
  • End Page

  • 62.e7
  • Volume

  • 207
  • Issue

  • 1