Heart transplantation for radiation-associated end-stage heart failure

Academic Article


  • Radiation-induced heart disease is an increasingly recognized late sequela of mediastinal radiation therapy for malignant neoplasms. We report four cases of heart transplantation for end-stage heart failure induced by mediastinal radiation therapy. Short-term and intermediate-term results are excellent with all four patients currently surviving a mean of 48 months after transplantation. Neither a second malignancy nor recurrence of the primary malignancy has been observed to date. The early results of heart transplantation for end-stage, radiation-induced heart disease are encouraging.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 10774687
  • Author List

  • Handa N; McGregor CGA; Daly RC; Dearani JA; Edwards BS; Frantz RP; Olson LJ; Rodeheffer RJ
  • Start Page

  • 162
  • End Page

  • 165
  • Volume

  • 13
  • Issue

  • 2