A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells

Academic Article

Abstract

  • Purmorphamine, which is a 2,6,9-trisubstituted purine compound, was discovered through cell-based high-throughput screening from a heterocycle combinatorial library. It differentiates multipotent mesenchymal progenitor cells into an osteoblast lineage. It will serve as a unique chemical tool to study the molecular mechanisms of osteogenesis of stem cells and bone development. Copyright © 2002 American Chemical Society.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Wu X; Ding S; Ding Q; Gray NS; Schultz PG
  • Start Page

  • 14520
  • End Page

  • 14521
  • Volume

  • 124
  • Issue

  • 49