Successful cognitive aging and health-related quality of life in younger and older adults infected with HIV

Academic Article


  • Neurocognitive impairments commonly occur and adversely impact everyday functioning in older adults infected with HIV, but little is known about successful cognitive aging (SCA) and its health-related quality of life (HRQoL) correlates. Seventy younger (≤40 years) and 107 older (≥50 years) HIV? adults, as well as age-matched seronegative comparison groups of younger (N = 48) and older (N = 77) subjects completed a comprehensive battery of neuropsychological, psychiatric, medical, and HRQoL assessments. SCA was operationalized as the absence of both performance-based neurocognitive deficits and self-reported symptoms (SCA-ANDS) as determined by published normative standards. A stair-step decline in SCA-ANDS was observed in accordance with increasing age and HIV serostatus, with the lowest rates of SCAANDS found in the older HIV? group (19 %). In both younger and older HIV? adults, SCA-ANDS was strongly related to better mental HRQoL. HIV infection has additive adverse effects on SCA, which may play a unique role in mental well-being among HIV-infected persons across the lifespan. © Springer Science+Business Media New York 2014.
  • Published In

  • AIDS and Behavior  Journal
  • Digital Object Identifier (doi)

    Author List

  • Moore RC; Fazeli PL; Jeste DV; Moore DJ; Grant I; Woods SP
  • Start Page

  • 1186
  • End Page

  • 1197
  • Volume

  • 18
  • Issue

  • 6