Physical Activity is Associated with Better Neurocognitive and Everyday Functioning Among Older Adults with HIV Disease

Academic Article


  • We examined the association between physical activity (PA), neurocognitive impairment (NCI), and instrumental activities of daily living (IADLs) among older HIV+ persons. One hundred older HIV+ adults completed the International Physical Activity Questionnaire, a neurocognitive battery, and IADL scale. Higher levels of moderate PA were associated with lower odds of NCI (p = 0.01), even when covariates were modeled. The association between moderate PA and NCI was driven by executive function (p = 0.04). Higher levels of moderate PA were also associated with lower odds of IADL Dependence (p = 0.03), although this fell to a trend (p = 0.08) when including covariates. Follow-up analysis showed those with both NCI and IADL Dependence had lower moderate PA than those with neither (p = 0.03). While these cross-sectional findings suggest PA is associated with better neurocognitive and everyday functioning in older HIV+ adults, longitudinal studies utilizing objective PA methods are needed to evaluate directionality and mechanisms.
  • Published In

  • AIDS and Behavior  Journal
  • Digital Object Identifier (doi)

    Author List

  • Fazeli PL; Marquine MJ; Dufour C; Henry BL; Montoya J; Gouaux B; Moore RC; Letendre SL; Woods SP; Grant I
  • Start Page

  • 1470
  • End Page

  • 1477
  • Volume

  • 19
  • Issue

  • 8