Acute macular neuroretinopathy is a rare disorder characterized by the sudden onset of unilateral or bilateral paracentral scotomas with relative sparing of the central vision that occurs mostly in young women. It is often characterized by wedge-like macular lesions. The cause of acute macular neuroretinopathy is unknown but viral, immunological, and vascular etiologies have been proposed. There is no current treatment and the visual prognosis is variable. We describe a young woman in whom this disorder was associated with the administration of epinephrine. © 2009 Elsevier Inc. All rights reserved.