Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thrombocytopenia

Academic Article


  • Heparin-induced thrombocytopenia (HIT) is an increasingly common clinical finding in patients presenting for cardiac transplantation. Bivalrudin, a reversible direct thrombin inhibitor, is a molecular anti-coagulant with short half-life and the potential for removal by intraoperative hemofiltration. Herein we describe the dosing and intraoperative management of bivalrudin anti-coagulation in a patient undergoing urgent cardiac transplantation in the context of recently diagnosed HIT. Copyright © 2005 by the International Society for Heart and Lung Transplantation.
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    Author List

  • Mann MJ; Tseng E; Ratcliffe M; Strattman G; De Silva A; DeMarco T; Achorn N; Moskalik W; Hoopes C
  • Start Page

  • 222
  • End Page

  • 225
  • Volume

  • 24
  • Issue

  • 2