Remyelination by oligodendrocytes stimulated by antiserum to spinal cord

Academic Article

Abstract

  • The new synthesis of myelin and the proliferation of oligodendrocytes was stimulated by serum from syngeneic mice immunized with homogenized spinal cord (SCH). Treatment with this antiserum produced a 10-fold increase in the area of remyelination in spinal cords that had become demyelinated previously as a result of infection by Theiler’s murine encephalomyelitis virus. Inflammation was decreased in regions of white matter that showed remyelination. Oligodendrocytes exposed to anti-SCH in vitro incorporated three to five times more [3H]thymidine than resting cells did and expressed more myelin basic protein in their cytoplasm, suggesting stimulation of myelinogenesis. Thus, there is a factor present in anti-SCH antiserum that stimulates central nervous system-type remyelination. This finding may provide clues for the therapy of patients with demyelinating disorders such as multiple sclerosis. © 1987 by the American Association of Neuropathologists.
  • Digital Object Identifier (doi)

    Author List

  • Rodriguez M; Lennon VA; Benveniste EN; Merrill JE
  • Start Page

  • 84
  • End Page

  • 95
  • Volume

  • 46
  • Issue

  • 1