gp120-mediated alterations in astrocyte ion transport

Academic Article


  • The pathogenesis of the acquired immuno-deficiency syndrome (AIDS) dementia complex (ADC) is unknown. However, recent work indicates that neurons and astrocytes are functionally compromised by exposure to viral components or cellular factors released from HIV-1-infected macrophages/microglia. We show that exposure of primary cultured rat astrocytes to the major HIV envelope glycoprotein gp120 results in alterations of ion and solute transport that may contribute to neuronal cell injury. © 1994 Elsevier Science Ltd.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Benos DJ; Hahn BH; Shaw GM; Bubien JK; Benveniste EN
  • Start Page

  • 175
  • End Page

  • 179
  • Volume

  • 4
  • Issue

  • 3