Magnetic coupling between water and creatine protons in human brain and skeletal muscle, as measured using inversion transfer 1H-MRS

Academic Article


  • Using the inversion transfer technique, the possible magnetic coupling between water protons and the protons of low-molecular weight metabolites was investigated in human brain and skeletal muscle at 1.5 T. The localized 1H-MR spectra were recorded at different times after selective inversion of the water resonance. Water inversion led to a significant transient reduction in the signal intensity of the methyl protons of creatine/phosphocreatine, in both tissues. This is indicative of magnetic coupling between the protons of water and those of creatine/phosphocreatine. Neither the choline and N-acetylaspartate protons in brain nor the protons of the trimethylammonium pool in skeletal muscle showed a significant magnetic coupling to mobile water. Copyright © 2001 John Wiley & Sons, Ltd.
  • Published In

  • NMR in Biomedicine  Journal
  • Digital Object Identifier (doi)

    Author List

  • Patton HK; Chu WJ; Hetherington HP; Hollander JD; Stewart KE; Raper JL; Shelton BJ; Benveniste EN; Benos DJ
  • Start Page

  • 1
  • End Page

  • 4
  • Volume

  • 14
  • Issue

  • 1