Effects of naltrexone on repressive coping and disclosure of emotional material: A test of the opioid-peptide hypothesis of repression and hypertension

Academic Article


  • OBJECTIVE: The present study was designed to assess the role of endogenous opioids in the relationship of hypertension to repressive coping. METHODS: Ten hypertensive and 8 normotensive males were given either the opioid antagonist naltrexone or placebo in a randomized, double-blind fashion over the course of four laboratory sessions. Measures of repression and disclosure were completed and blood pressure was assessed during a laboratory stressor protocol. RESULTS: Opioid antagonism reduced repression and increased disclosure only in the hypertensive group. Also, opioid antagonism increased stress-related systolic blood pressure only in the hypertensive group. CONCLUSION: The results support the hypothesis that endogenous opioid dysregulation underlies both hypertension and repressive phenomena. Copyright © 2006 by the American Psychosomatic Society.
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    Digital Object Identifier (doi)

    Author List

  • Younger JW; Lawler-Row KA; Moe KA; Kratz AL; Keenum AJ
  • Start Page

  • 734
  • End Page

  • 741
  • Volume

  • 68