Circadian regulation of kidney function: Finding a role for bmal1

Academic Article

Abstract

  • Mounting evidence suggests that there is an internal molecular “clock” within the kidney to help maintain normal renal function. Disturbance of the kidney circadian rhythm may pose a threat to water and electrolyte homeostasis and blood pressure regulation, among many other problems. The identification of circadian genes facilitated a more comprehensive appreciation of the importance of “keeping the body on time”; however, our knowledge is very limited with regard to how circadian genes regulate kidney function. In this brief review, we summarize recent progress in circadian control of renal physiology, with a particular focus on aryl hydrocarbon receptor nuclear translocator-like protein (Arntl1; also called Bmal1).
  • Authors

    Digital Object Identifier (doi)

    Pubmed Id

  • 21254934
  • Author List

  • Zhang D; Pollock DM
  • Start Page

  • F675
  • End Page

  • F678
  • Volume

  • 314
  • Issue

  • 5