Long-lived species have improved proteostasis compared to phylogenetically-related shorter-lived species

Academic Article


  • Our previous studies have shown that the liver from Naked Mole Rats (NMRs), a long-lived rodent, has increased proteasome activity and lower levels of protein ubiquitination compared to mice. This suggests that protein quality control might play a role in assuring species longevity. To determine whether enhanced proteostasis is a common mechanism in the evolution of other long-lived species, here we evaluated the major players in protein quality control including autophagy, proteasome activity, and heat shock proteins (HSPs), using skin fibroblasts from three phylogenetically-distinct pairs of short- and long-lived mammals: rodents, marsupials, and bats. Our results indicate that in all cases, macroautophagy was significantly enhanced in the longer-lived species, both at basal level and after induction by serum starvation. Similarly, basal levels of most HSPs were elevated in all the longer-lived species. Proteasome activity was found to be increased in the long-lived rodent and marsupial but not in bats. These observations suggest that long-lived species may have superior mechanisms to ensure protein quality, and support the idea that protein homeostasis might play an important role in promoting longevity.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Pride H; Yu Z; Sunchu B; Mochnick J; Coles A; Zhang Y; Buffenstein R; Hornsby PJ; Austad SN; PĂ©rez VI
  • Start Page

  • 669
  • End Page

  • 675
  • Volume

  • 457
  • Issue

  • 4