Extracorporeal photopheresis practice patterns: An international survey by the ASFA ECP subcommittee

Academic Article


  • Background: Although many apheresis centers offer extracorporeal photopheresis (ECP), little is known about current treatment practices. Methods: An electronic survey was distributed to assess ECP practice internationally. Results: Of 251 responses, 137 met criteria for analysis. Most respondents were from North America (80%). Nurses perform ECP at most centers (84%) and the majority of centers treat adults only (52%). Most centers treat fewer than 50 patients/year (83%) and perform fewer than 300 procedures/year (70%). Closed system devices (XTS and/or Cellex) are used to perform ECP at most centers (96%). The most common indications for ECP are acute/chronic skin graft versus host disease (89%) and cutaneous T-cell lymphoma (63%). The typical wait time for ECP treatment is less than 2 weeks (91%). Most centers do not routinely perform quality control assessment of the collected product (66%). There are device-specific differences in treatment parameters. For example, XTS users more frequently have a minimum weight limit (P = 0.003) and use laboratory parameters to determine eligibility for treatment (P = 0.03). Regardless of device used, the majority of centers assess the clinical status of the patient before each procedure. Greater than 50% of respondents would defer treatment for hemodynamic instability due to active sepsis or heart failure, positive blood culture in the past 24 h or current fever. Conclusion: This survey based study describes current ECP practices. Further research to provide evidence for optimal standardization of patient qualifications, procedure parameters and product quality assessment is recommended.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Dunbar NM; Raval JS; Johnson A; Abikoff CM; Adamski J; Cooling LL; Grossman B; Kim HC; Marques MB; Morgan S
  • Start Page

  • 215
  • End Page

  • 223
  • Volume

  • 32
  • Issue

  • 4