Presenting characteristics of trisomy 8 as the primary cytogenetic abnormality associated with childhood acute lymphoblastic leukemia. A pediatric oncology group (POG) study (8600/8493)

Academic Article


  • Although trisomy 8 is the single most common numerical abnormality in acute myeloid leukemia (AML), relatively few cases with acute lymphoblastic leukemia (ALL) and trisomy 8 have been reported. We report the clinical and laboratory features of seven children with ALL and trisomy 8 as the sole cytogenetic abnormality and review nine similar cases from the literature. Among the children studied by the Pediatric Oncology Group (POG) with newly diagnosed ALL, only 0.3% had trisomy 8 as the sole abnormality. Four of our patients had T-cell ALL and three had early pre-B ALL. Presenting clinical features were typical for the respective immunophenotypes. Six of the seven children achieved complete remission. Our study suggest that trisomy 8 is an infrequent, recurring abnormality among children with ALL, which appears to be associated with a T-cell immunophenotype. © 1994.
  • Published In

  • Cancer Genetics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Pettenati MJ; Rao N; Wofford M; Shuster JJ; Pullen DJ; Ling MP; Steuber CP; Carroll AJ
  • Start Page

  • 6
  • End Page

  • 10
  • Volume

  • 75
  • Issue

  • 1