Coding sequences of the ral-1 gene are disrupted by chromosome translocation in human T cell leukemia

Academic Article

Abstract

  • The tal-1 proto-oncogene encodes a helix-loop-helix DNAbinding protein that has been implicated in the formation of T cell acute lymphoblastic leukemia (TALL). Patients with TALL harbor structural rearrangements of tal-1 that result from either local DNA deletion or t(1 ;14)(p34;gll) chromosome translocation. By analyzing t(1;14)(p34;gll) chromosomes from a series ofpatients, we have now identified a discrete region of tal-1 wherein most of the translocation breakpoints occur. Moreover, mapping of tal-1 genomic DNA revealed that coding exons are situated on both sides of the t(1 ;14)(p34;gll) major breakpoint region. Hence, the translocated allele of tal-1 is truncated in a manner that reduces its amino acid coding potential. © 1990, Rockefeller University Press., All rights reserved.
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    Digital Object Identifier (doi)

    Author List

  • Chen Q; Ying-Chuan Yang C; Tsan JT; Xia Y; Ragab AH; Peiper SC; Carroll A; Baer R
  • Start Page

  • 1403
  • End Page

  • 1408
  • Volume

  • 172
  • Issue

  • 5