Due to advanced antiretroviral treatments, persons with HIV/AIDS (PWH/As) live longer and experience various physical and cognitive impairments during the course of their disease. Often, informal caregivers assist PWH/As to manage these impairments and experience negative physical and psychosocial consequences from their role. This article reviews and analyzes published empirical studies that have examined physical and psychosocial outcomes in informal caregivers of PWH/As. Gaps and limitations of current research are discussed. Recommendations for future research and practice implications are also proposed.