TOPIC. The nature vs. nurture argument as it pertains to two brothers. PURPOSE. To explore the synergistic effects of heritability and environment in the cases of two brothers with schizophrenia. SOURCES. Review of the literature and the authors' clinical experience. CONCLUSIONS. The nature vs. nurture dichotomy may not be as relevant as looking at the interaction between these two forces. Search terms: Family, nature, nurture, schizophrenia.