Myocardial and pulmonary histopathologic changes

Academic Article

Abstract

  • The deleterious effects of catecholamines on the heart have been widely recognized for a long time, and the cardiotoxic effects of amines have been reviewed recently. Exogenous catecholamines administered in large doses comprise a classic means of producing experimental or iatrogenic myocardial necrosis. Overproduction of endogenous catecholamines derived from adrenal pheochromocytomas, tetanus toxin-induced overstimulation of the nervous system, effects of raised intracranial pressure, cocaine abuse, and the effects of drowning on the heart, may all produce myocyte necrosis via the action of excessive amounts of catecholamines from the adrenal glands, adrenal tumors, or sympathetic nerve endings. In certain circumstances (eg, pheochromocytoma), all of the excess catecholamines may be derived from the tumor, while in others (eg, subarachnoid hemorrhage), the excess may be from sympathetic neurons as well as from the adrenal glands.
  • Authors

    Published In

    Author List

  • Rose AG; Novitzky D; Cooper DKC
  • Start Page

  • 29
  • End Page

  • 32
  • Volume

  • 20
  • Issue

  • 5 SUPPL. 7