Impairment of renal slice function following brain death, with reversibility of injury by hormonal therapy

Academic Article


  • The effects of the agonal period and subsequent donor management on renal slice function, using the K+ – Na++ ratio, have been studied in the pig. Brain ischaemia or death resulted in a reduction in renal slice function, whether the pig was maintained normovolemic or bypovolemic by i.v. fluid and dobutaminc therapy. This deterioration in function was, however, reversed or prevented by a period of therapy with thyroxine (T3), insulin, and cortisol. A period of 24 hr storage of the kidney slice in a low ionic strength solution in ice resulted in a further deterioration in slice function in all groups studied. © 1986 by The Williams & Wilkins Co.
  • Authors

    Published In

  • Transplantation  Journal
  • Digital Object Identifier (doi)

    Author List

  • Wicomb WW; Cooper DKC; Novitzky D
  • Start Page

  • 29
  • End Page

  • 32
  • Volume

  • 41
  • Issue

  • 1