Cardiac Transplantation Following Storage of the Donor Heart by a Portable Hypothermic Perfusion System

Academic Article

Abstract

  • Four patients have undergone heterotopic heart transplantation with donor hearts stored by a portable hypothermic perfusion system. Total ischemic periods ranged from 6 hours 55 minutes to 16 hours 50 minutes. One heart, transplanted into a patient who had acutely rejected a previous graft, suffered accelerated, irreversible, acute rejection within five days, associated with strong antibody formation; donor heart function was never good. In the 3 remaining patients, donor heart function was good after initially being poor for a few hours in 2 patients. One patient died of long-term rejection after 6 months and 1 of tuberculous meningitis after 10 months; 1 remains alive at 15 months. Neither preservation of the donor heart for periods in excess of approximately 4 hours nor the use of continuous hypothermic perfusion as a method of preservation appears to have been reported previously in the context of the clinical situation. © 1984, The Society of Thoracic Surgeons. All rights reserved.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Wicomb WN; Cooper DKC; Novitzky D; Barnard CN
  • Start Page

  • 243
  • End Page

  • 248
  • Volume

  • 37
  • Issue

  • 3