Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience

Academic Article

Abstract

  • Hearts from α1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody-based regimen. The elimination of the galactose-α1,3-galactose epitope prevented hyperacute rejection and extended survival of pig hearts in baboons for 2-6 months (median, 78 d); the predominant lesion associated with graft failure was a thrombotic microangiopathy, with resulting ischemic injury. There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GaIT-KO pigs increased graft survival over previous studies.
  • Authors

    Published In

  • Nature Medicine  Journal
  • Digital Object Identifier (doi)

    Author List

  • Kuwaki K; Tseng YL; Dor FJMF; Shimizu A; Houser SL; Sanderson TM; Lancos CJ; Prabharasuth DD; Cheng J; Moran K
  • Start Page

  • 29
  • End Page

  • 31
  • Volume

  • 11
  • Issue

  • 1