Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys

Academic Article

Abstract

  • We transplanted kidneys from α1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GalT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans. © 2005 Nature Publishing Group.
  • Authors

    Published In

  • Nature Medicine  Journal
  • Digital Object Identifier (doi)

    Author List

  • Chen G; Qian H; Starzl T; Sun H; Garcia B; Wang X; Wise Y; Liu Y; Xiang Y; Copeman L
  • Start Page

  • 1295
  • End Page

  • 1298
  • Volume

  • 11
  • Issue

  • 12