Recent advances in pig-to-human organ and cell transplantation

Academic Article

Abstract

  • Xenotransplantation using pigs offers the prospect of an unlimited number of organs and cells for clinical transplantation. A major step forward has been achieved with the introduction of pigs homozygous for α1,3-galactosyltransferase gene-knockouts that do not express the major antigenic target for primate antipig antibodies (i.e., Galα1,Gal). Heterotopic heart transplants have survived for 2-6 months in baboons. However, other immune and pathophysiologic barriers remain, including: i) anti-non-Gal antibodies and cells of the innate immune system; and ii) thrombogenesis associated with incompatibilities in the coagulation-anticoagulation systems of pig and primate. Further genetic modification of the organ-source pig to overcome these barriers is being undertaken. © 2008 Informa UK Ltd.
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    Digital Object Identifier (doi)

    Author List

  • Cooper DKC; Ezzeiarab M; Hara H; Ayares D
  • Start Page

  • 1
  • End Page

  • 4
  • Volume

  • 8
  • Issue

  • 1