Defining the communication between agonist and coactivator binding in the retinoid x receptor α ligand binding domain

Academic Article


  • Background: Some retinoid X receptor (RXR) agonists have potential as cancer drugs. Results: Structures of RXR in complex with two different agonists show similar folds. Dynamics analysis reveals unique ligand-induced dynamics in helices 3, 11, and 12. Conclusion: Two networks of interactions that connect RXR agonists to coactivator binding are defined. © 2014 by the American Society for Biochemistry and Molecular Biology, Inc. .
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Boerma LJ; Xia G; Qui C; Cox BD; Chalmers MJ; Smith CD; Lobo-Ruppert S; Griffin PR; Muccio DD; Renfrow MB
  • Start Page

  • 814
  • End Page

  • 826
  • Volume

  • 289
  • Issue

  • 2