Na,K-ATPase α- and β-isoforms in the developing cochlea of the mouse

Academic Article


  • Immunohistochemistry was used to investigate the presence of Na,K-ATPase α- and β-subunits isoforms (α , α , α , β and β ) in the cochlea of the mouse at different ages between embryological day (E) 19 and postnatal day (P)+30. α was mainly found in the stria vascularis and in the spiral ligament; it increased steadily from p+4. These data correlates well with the morphological and electrophysiological maturation of the cochlea. α predominated in the spiral ganglia and the cochlear nerve. This finding is well in accordance with reports that α seems to be associated with the nervous system. The β-subunit was found mainly in those tissues where staining of the α-subunit also was seen. Both subunits were localized in tissue regions where fluid regulation is expected to play an important role. For some isoforms, the expression pattern of Na,K-ATpase during development in the mouse is different from that in the rat. The expression of Na,K-ATPase and that of glucocorticoid receptors during development in the inner ear of the mouse show a similar pattern, which may indicate that glucocorticoid receptors could be involved in regulating the expression of Na,K-ATPase. 1 2 3 1 2 1 3 3
  • Authors

    Published In

  • Hearing Research  Journal
  • Digital Object Identifier (doi)

    Author List

  • Erichsen S; Zuo J; Curtis L; Rarey K; Hultcrantz M
  • Start Page

  • 143
  • End Page

  • 149
  • Volume

  • 100
  • Issue

  • 1-2